The Montana girls led Wyoming 40-26 at the half and pulled away for an 86-60 victory Saturday in Billings to complete the weekend sweep.
Gillette's Kalina Smith, who was named Miss Wyoming Basketball on Friday, led the Cowboy State team with 17 points.
Buffalo's Ashley Tehau added 13 points and Worland's Lyndzi Rich pitched in 11 points and five rebounds. Cheyenne East's Cosette Stellern grabbed a team-high eight rebounds to go with five points.
Montana now leads the all-time series 29-13.